Preprint claiming that COVID-19 mRNA vaccines cause transcriptomic dysregulation is deeply flawed

Today, 25 July 2025, a preprint was posted claiming that significant gene expression changes were found in individuals with new-onset cancer and other diseases after receiving mRNA COVID-19 vaccines, compared to healthy individuals.

A preprint is a non-peer reviewed manuscript – a study or hypothesis that has not yet been evaluated by other scientists. These articles should always be read with caution. Preprints can be brilliant, misguided, or completely bonkers – but they have not been peer-reviewed.

So let’s take a closer look at this preprint.

Update, 12 September 2025: The preprint was withdrawn for “unresolved ethical issues concerning ethical oversight, legitimacy of institutional boards, validity of the study design, and potential biases in study interpretation that compromise the overall trust in the research findings.

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A MAGIcal Special ERMPS Issue

The European Review for Medical and Pharmacological Sciences continues to be a safe space for paper mills and very low-quality articles. Its special December issue (Supplement 6) is filled with 16 papers, all written by the same author, who appears to be using the journal as one big advertisement for his MAGI supplement-selling business. No conflicts of interest to declare!

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