Over the last week I’ve been analyzing a set of papers from a research group at Brigham and Women’s Hospital, which falls under the Harvard Medical School. The papers have the usual image problems we unfortunately encounter so often, such as duplicated photos of mice and overlapping Western blots.
But this set also includes a 2022 paper that appears to have copied/pasted several figure panels from other researchers and even from scientific vendors. Most of these problems were found with ImageTwin or reverse image searches.
Quick links [the spreadsheet and slide have been updated with an additional problem found on Feb 2, 2024]:
spreadsheet with the 28 29 papers found with PubPeer links [Excel file]
slide deck with the 58 59 image problems found in the 28 29 papers [PDF].
In a report shared with Science in October 2023, a committee investigating allegations of misconduct by Dr. Hoau-Yan Wang, a professor at the City College of New York (CCNY, which falls under the City University of New York (CUNY)), found evidence that was ‘highly suggestive of deliberate scientific misconduct’. Dr. Wang has been a frequent collaborator with Cassava Sciences (Nasdaq: SAVA), a biotech company working on a drug called simufilam for the treatment of Alzheimer’s disease. Unfortunately, Dr. Wang was unable to provide the committee with any original data or notebooks that could have addressed concerns about his work. Although the suspicions of manipulated images could therefore not be proved, the investigation revealed “long-standing and egregious misconduct in data management and record keeping by Dr. Wang”.
This post describes a set of over 20 papers with mostly image problems from the Department of Pharmacology at the School of Medicine of Zhejiang University in Hangzhou, China. All papers have Professor Ximei Wu as the common – and often corresponding – author. The Wu lab conducts research on stem cell and bone development, and their papers contain many images of Western blots and immunohistochemistry experiments.
This blog post expresses my personal opinion. It is not an accusation of misconduct.
Update October 2020: The list of Annamalai University papers with concerns has grown to 229. Here is the list, with links to the PubPeer posts, as an Excel file and as a PDF.
Annamalai University
Annamalai (often spelled “Annaamalai”) is the name of an Indian hit-movie from 1992. It is also the name of a state university in Tamil Nadu, a state in the South of India.
Annamalai University Logo with its motto “With Courage And Faith”