A group of anonymous persons filed a Statement of Concern with the FDA regarding the integrity of research papers about Simufilam, an Alzheimer’s Disease treatment drug candidate developed by Cassava Sciences (Nasdaq: $SAVA). The petition raises concerns about Western blots and methodology. I took a look at the problematic photos included in the report, and agree with most of those concerns. I also found some additional problems.
Continue reading “Cassava Sciences: Of stocks and blots”Category: Image Concerns
Concerns about Marseille’s IHUMI/AMU papers – Part 1
Last March, I shared my concerns about a paper from the IHU-Méditerranée Infection (IHUMI)/ Aix-Marseille University (AMU) claiming that Hydroxychloroquine in combination with Azithromycin could reduce coronavirus viral loads faster than no treatment.
Other papers by this group of researchers led by Professor Didier Raoult and/or his right-hand man Professor Eric Chabrière, also appear to contain problems, ranging from potentially duplicated images to ethical concerns.
In this blog post I have gathered the papers by the Raoult and Chabrière group that have image concerns. This post is not an accusation of misconduct, but a compilation of the potential problems found in 22 different papers by this group. I welcome the authors removing any concerns by providing the original figures.
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Northeastern University professor with 69 papers on PubPeer has resigned
A chemistry professor at Northeastern University in Boston, MA who has almost 70 papers flagged on PubPeer resigned yesterday, May 4, 2021.
On his blog For Better Science (Update May 5, at the bottom), Leonid Schneider shared an email from the Chair of the Department of Engineering, which states that Thomas J Webster has resigned from the university.
Webster has 69 papers flagged on PubPeer, mostly for concerns about image irregularities. I reported 59 to the journals and institution in March 2020.
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Similar images from the Technion
The Technion-Israel Institute of Technology is the oldest university in Israel, ranking itself ‘among the world’s top science and technology research universities’.
It is here that a group of researchers appears to have been publishing remarkably similar photos for the last decade — or more.
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Forty five papers from Tianjin Medical University
This week I worked on a large set of papers from a research group at the Tianjin Life Science Research Center at Tianjin Medical University. The group, headed by Dr. Hua Tang and funded by many National Natural Science Foundation of China grants, has published a total of 113 PubMed-indexed papers.
However, a significant number of these — 45 as of today — have PubPeer posts in which concerns are raised about their figures.
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Science paper from Dutch top-institute retracted
A 2007 paper published in Science — in which I found image irregularities back in 2015 — has finally been retracted. For five long years, the journal took no action. But after I tweeted about the case, it eventually acted.
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Troubles with VSELs
A stem cell research group at the University of Louisville, Kentucky — famous for apparently discovering an exciting new class of stem cells — could be facing new troubles.
Although the work of Mariusz Ratajczak was supported through large NIH and Vatican grants, no other lab could replicate his findings on very small embryonic-like stem cells (VSELs).
And now, 28 papers from the Ratajczak lab are listed on PubPeer for image duplication and textual similarity concerns.
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“Nanomedicine: Nanotechnology, Biology and Medicine” wins third “This Image Is Fine” Award
When it comes to image integrity, all papers are equal. But some papers appear more equal than others. A 2017 paper published in Elsevier’s journal Nanomedicine: Nanotechnology, Biology and Medicine that included an image with lots of repetitive elements was not retracted, but instead received only a very mild correction for “an inadvertent mistake for Figure 3,B” (sic). One of the senior authors also happens to be an Associate Editor of the journal, raising questions about whether the investigation could have been carried out in an objective way.
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46 papers from a Royan Institute professor
The Royan Institute in Tehran, Iran was initially founded in 1991 as a research institute for infertility treatments. It now consists of three research institutes, one of which is the Royan Institute for Stem Cell Biology and Technology (RI-SCBT), which was founded in 2002 by Hossein Baharvand, its director.
Professor Hossein Baharvand has received many national and international awards, including three Razi research awards, the 2014 UNESCO-Equatorial Guinea International Prize for Research in Life Sciences, a 2019 TWAS Prize, and the 2019 Mustafa Prize. He has an H-index of 57, with nearly 400 papers on PubMed. And, as of today, 46 of those papers have PubPeer comments because of image concerns or undisclosed conflicts of interest.
TL:DR: Excel spreadsheet – PDF version
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Big trouble in a nanoparticles lab
After an anonymous tip about some papers by the Şen Research Group with possible duplicated graphs, I started digging around a bit more. And I found a couple more papers with duplications. And more. Quite a lot more. As of now, the SRG has 84 papers flagged on PubPeer. [Excel spreadsheet; PDF version]
Continue reading “Big trouble in a nanoparticles lab”
