Problems in Harvard Medical School studies include images taken from other researchers’ papers and vendor websites

Over the last week I’ve been analyzing a set of papers from a research group at Brigham and Women’s Hospital, which falls under the Harvard Medical School. The papers have the usual image problems we unfortunately encounter so often, such as duplicated photos of mice and overlapping Western blots.

But this set also includes a 2022 paper that appears to have copied/pasted several figure panels from other researchers and even from scientific vendors. Most of these problems were found with ImageTwin or reverse image searches.

Quick links [the spreadsheet and slide have been updated with an additional problem found on Feb 2, 2024]:

  • spreadsheet with the 28 29 papers found with PubPeer links [Excel file]
  • slide deck with the 58 59 image problems found in the 28 29 papers [PDF].
An image that appears to have been copied from a scientific seller’s website.
See: https://pubpeer.com/publications/FF5706E8826CB8D45481E942A679EE
Continue reading “Problems in Harvard Medical School studies include images taken from other researchers’ papers and vendor websites”

January 2024 news

Here is a summary of some recent news articles about problematic science papers and the tools used to detect them.

Dana-Farber Cancer Institute problems

The main science integrity story in the past month concerned a set of ~50 papers from four research groups at the Dana-Farber Cancer Institute (DFCI) found by molecular biologist Sholto David from Wales. He first blogged about the set on January 2nd in a guest post on Leonid Schneider’s For Better Science site. Using ImageTwin to scan scientific articles, he discovered image duplication problems in about 30 of these papers. His blog post also included issues with papers from the same researchers, previously flagged by other (anonymous) image sleuths on PubPeer.

This story was then reported by Veronica H. Paulus and Akshaya Ravi of the Harvard Crimson, a student-run newspaper, on January 12. A week later, Angus Chen and Jonathan Wosen reported on the case at STAT News.

Typically with such allegations, the institutions issue a standard reply saying they take breaches of scientific integrity very seriously, and that they will investigate – followed by months or years of silence. But this case was different. On January 22, just three weeks after David’s blog post came out, DFCI responded that they had already investigated most of the cases reported by David, and said that 6 papers would be retracted, and another 31 corrected.

Some other coverage of this story:

Stories about Sholto David

Related to the DFCI story above, several interviews focusing on the work and motivation of Sholto David have been published. Similar to the way in which many other science image-forensics detectives — including myself — work, Dr. David uses both his eyes and software (ImageTwin) to scan scientific papers for image problems. Here are some of the recent profiles:

Plagiarism in dissertations of high-profile persons

At the beginning of this month Dr. Claudine Gay, the president of Harvard University, resigned from her position after receiving criticism for how she and two other top-university presidents handled a Congress hearing about antisemitism on campus, and also for allegations of plagiarism in her PhD thesis. Most criticisms came from conservative people and news sites, turning plagiarism allegations into a political weapon against ‘wokism’ with undertones of racism (Dr. Gay is Black). 

Having said that, the plagiarism allegations were credible and real. And it seems fair to have the same standards for university presidents and professors as universities expect students to adhere to.

Business Insider then reported on a similar case of plagiarism in the Harvard dissertation of designer and artist Dr. Neri Oxman, the wife of billionaire Bill Ackman, who was one of the critics of Dr. Gay’s position. Ackman responded on X with some very long tweets basically arguing that the plagiarism of his wife was ‘good plagiarism’ and that of Dr. Gay ‘bad plagiarism’, without convincing me that there was any difference. Ackman was even threatening to sue Business Insider, adding to the emerging picture that science misconduct cases may no longer be investigated based on legitimate allegations of misconduct, but might instead be dismissed by rich people who can afford expensive lawyers to dismiss such allegations because of ‘defamation’. A worrying development that will not serve scientific integrity.

This week, Harvard’s Chief Diversity and Inclusion Officer Sherri A. Charleston was also accused of plagiarism in her PhD thesis.

Additional coverage of this story:

Plagiarism in a professor’s PhD thesis as analyzed by SimTexter, https://people.f4.htw-berlin.de/~weberwu/simtexter/app.html

Some more articles of interest

All that glitters is not gold

This blog post is not an accusation of misconduct, and reflects my personal opinion.

This paper has it all. The authors are from Stanford University’s School of Medicine and Harvard Medical School. It was published in 2002 in Nature Medicine, and has been cited over 900 times, as per Google Scholar. It even received a prestigious F1000 Recommendation. And it was supported by six NIH grants.

Akbari O et al. Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nature Medicine 8(9), September 2002. DOI: 10.1038/nm745.
It glitters. But is it gold? Photo by Lucas Benjamin on Unsplash

But all that glitters is not gold. Let’s take a look at some of the flow cytometry images in this paper.

Continue reading “All that glitters is not gold”