Fatty acids, STAT3, and unexpected image similarities

This blog post expresses my personal opinion and is not an accusation of misconduct.

An exciting new paper about STAT3

The STAT (“signal transducer and activator of transcription“) protein family consists of proteins involved in many important aspects of cellular function, such as growth, differentiation, and apoptosis (programmed cell death). These transcription activators are activated themselves if other molecules bind to them, and they act as messengers that transfer changes outside of a cell to inside the nucleus, by binding to promoters and determining which genes are switched on or off. One of STAT proteins, STAT3, in particular has been the topic of many studies, because it might play a role in cancer. Simply put, the continuous activation of STAT3 might induce cancer, and STAT3 might be a target for new anti-cancer drugs.

A recent study, published on 28 August 2019 in Nature by authors from Harvard Medical School and the Dana Farber Cancer Institute, therefore gained quite some attention. It reported on one of the ways by which STAT3 can be activated, through the binding of fatty acids in a process called palmitoylation.

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