After an anonymous tip about some papers by the Şen Research Group with possible duplicated graphs, I started digging around a bit more. And I found a couple more papers with duplications. And more. Quite a lot more. As of now, the SRG has 84 papers flagged on PubPeer. [Google Sheet link]Continue reading “Big trouble in a nanoparticles lab”
How does one scan for duplicated images in scientific paper, and how can one determine if those are a sign of misconduct? This post will give some background about my past and current work on this topic.Continue reading “Scanning for duplications”
This blog post expresses my personal opinion and is not an accusation of misconduct.
An exciting new paper about STAT3
The STAT (“signal transducer and activator of transcription“) protein family consists of proteins involved in many important aspects of cellular function, such as growth, differentiation, and apoptosis (programmed cell death). These transcription activators are activated themselves if other molecules bind to them, and they act as messengers that transfer changes outside of a cell to inside the nucleus, by binding to promoters and determining which genes are switched on or off. One of STAT proteins, STAT3, in particular has been the topic of many studies, because it might play a role in cancer. Simply put, the continuous activation of STAT3 might induce cancer, and STAT3 might be a target for new anti-cancer drugs.
A recent study, published on 28 August 2019 in Nature by authors from Harvard Medical School and the Dana Farber Cancer Institute, therefore gained quite some attention. It reported on one of the ways by which STAT3 can be activated, through the binding of fatty acids in a process called palmitoylation.Continue reading “Fatty acids, STAT3, and unexpected image similarities”
A reader pointed out a 2016 paper published in Dermatologic Surgery.
Daily Use of a Facial Broad Spectrum Sunscreen Over One-Year Significantly Improves Clinical Evaluation of Photoaging – M. Randhawa et al. – Dermatologic Surgery: December 2016 – doi: 10.1097/DSS.0000000000000879Continue reading “Face value: sunscreen, lack of control group, and conflict-of-interest”
The Andrew Wakefield case
One of the best-known examples of data falsification is a study described in a 1998 Lancet paper with Dr. Andrew Wakefield as the lead author. In this paper, 12 children with autism and chronic enterocolitis were described, and these symptoms started immediately after MMR (Measles / Mumps / Rubella) vaccination in 8 of these children.
However, a 2004 investigation by Sunday Times reporter Brian Deer revealed concerning issues with patient recruitment and undisclosed financial conflicts of interest.Continue reading “Falsification: The Andrew Wakefield case”
In Part 1 and Part 2 of this series, I showed some examples of plagiarism and falsification in scientific papers, which the Office of Research Integrity (ORI) considers two of the three forms of Research Misconduct. Here, we will look at the third type of misconduct, fabrication. ORI defines fabrication as follows:
Continue reading “What is Research Misconduct? Part 3: Fabrication”
“Fabrication is making up data or results and recording or reporting them.”Office of Research Integrity: Definition of Research Misconduct
In Part 1 of this series, I showed some examples of plagiarism in scientific papers, which the Office of Research Integrity (ORI) considers one of the three forms of Research Misconduct. Here, we will look at the second type of misconduct, falsification. ORI defines falsification as follows:
Continue reading “What is Research Misconduct? Part 2: Falsification”
“Falsification is manipulating research materials, equipment, or processes, or changing or omitting data or results such that the research is not accurately represented in the research record.”Office of Research Integrity: Definition of Research Misconduct
Let’s clarify that a bit more with some examples. In this blog post, I will discuss plagiarism.Continue reading “What is Research Misconduct? Part 1: Plagiarism”